Bladder Cancer

Expert care tailored to your needs, combining advanced treatment with a focus on comfort and support.

What is Bladder Cancer?

Bladder cancer is a type of cancer that originates in the cells of the bladder, a hollow organ in the lower abdomen that stores urine. The most common type of bladder cancer is urothelial carcinoma, also known as transitional cell carcinoma, which begins in the urothelial cells lining the inside of the bladder.

Bladder cancer is a significant global health concern. It ranks as the 10th most common cancer worldwide, accounting for around 3.2% of all new cancer cases. The disease primarily affects older individuals, with most cases occurring in people over the age of 55. The global mortality rate is estimated to be approximately 2.8%.

These statistics provide a general overview of bladder cancer’s prevalence and impact both worldwide and in Singapore, emphasising the need for continued research, early detection, and effective treatment strategies to combat this disease.

Bladder Cancer
Bladder Cancer

How common is bladder cancer in the Philippines?

Bladder cancer is less common in the Philippines compared with major cancers like breast, lung, and colorectal cancer, which account for a much larger share of total cancer cases nationwide.  

Based on the IARC Global Cancer Observatory (GLOBOCAN 2022), the Philippines had an estimated 188,976 new cancer cases (all cancer types) in 2022. While bladder cancer represents a smaller portion of the overall cancer burden, it remains an important health concern, particularly because bladder cancer is generally more common in men.  

Globally, bladder cancer is among the most commonly diagnosed cancers, with an estimated 614,298 new cases and 220,596 deaths in 2022.  

Early evaluation and timely treatment are important, especially for symptoms such as blood in the urine, and patients are encouraged to consult a qualified doctor for proper assessment. 

What Are the Signs and Symptoms of Bladder Cancer?

The signs and symptoms of bladder cancer can vary, and some individuals may not experience any symptoms in the early stages. The most common symptoms include:

Hematuria (Blood in Urine)
The most noticeable symptom of bladder cancer is blood in the urine, also known as hematuria. Blood may appear either grossly (visible to the naked eye) or microscopically (detected only during urine testing) and is typically painless.
Bladder cancer can cause an increased urge to urinate frequently, often accompanied by a sense of urgency or discomfort during urination.
Some individuals may experience pain or a burning sensation during urination, often resulting from irritation or inflammation caused by the tumour.
Advanced bladder cancer may cause persistent pain in the lower back or pelvis, which may worsen over time.
Bladder cancer can lead to changes in urinary habits, such as increased frequency, urgency, or difficulty emptying the bladder completely.
In some cases, bladder cancer may cause fatigue and unexplained weight loss, symptoms more commonly associated with advanced stages of the disease.

Screening for Bladder Cancer

Unlike some other cancers, there are no standard screening tests recommended for the general population to detect bladder cancer in its early stages. This is because there is currently insufficient evidence to support the effectiveness of routine screening for this disease in individuals without specific risk factors or symptoms.

However, for certain high-risk individuals, such as those with a history of bladder cancer or exposure to certain occupational hazards, regular screening or surveillance may be recommended. The specific strategies may vary based on individual risk factors and medical history.

In general, if you have symptoms suggestive of bladder cancer, such as blood in the urine (hematuria), frequent urination, or persistent urinary tract infections, it is essential to consult a healthcare professional for proper evaluation. They may perform tests such as urine analysis, imaging studies (like ultrasound or CT scan), or cystoscopy (a procedure to examine the bladder using a thin tube with a camera) to help diagnose or rule it out.

Additionally, it’s worth noting that reducing exposure to known risk factors for bladder cancer, such as quitting smoking and minimising occupational exposure to certain chemicals, can help lower the risk of developing the disease.

How Bladder Cancer Is Diagnosed

Bladder cancer is typically diagnosed through a combination of medical history evaluation, physical examination, and diagnostic tests. The process may involve the following steps:

The doctor will begin by taking a detailed medical history, including any symptoms you may be experiencing and any risk factors you may have. They will also perform a physical examination to assess your overall health and look for signs or abnormalities.
A urine sample will be collected and analysed for the presence of blood, cancer cells, or other abnormalities. This test, known as urine cytology, can help detect cancerous cells in the urine.
Imaging tests such as ultrasound, computed tomography (CT) scan, or magnetic resonance imaging (MRI) may be performed to visualise the bladder and surrounding structures. These tests can help identify the presence, size, and location of any tumours or abnormalities.
Cystoscopy is a procedure in which a thin, flexible tube with a camera on the end, called a cystoscope, is inserted through the urethra and into the bladder. This allows the doctor to visualise the bladder directly and examine its lining for abnormalities, such as tumours. During cystoscopy, a biopsy may be taken, where small tissue samples are collected for further examination under a microscope.
If suspicious areas or tumours are detected during cystoscopy, a biopsy may be performed to confirm the presence of cancer cells. The collected tissue samples are sent to a laboratory where a pathologist examines them under a microscope to determine if they are cancerous and to determine the specific type and grade of bladder cancer.
Once a diagnosis of bladder cancer is confirmed, further tests may be conducted to determine the stage of the cancer and whether it has spread to other part.

What Are the Causes and Risk Factors of Bladder Cancer?

The exact causes of bladder cancer are not fully understood, but it is believed to develop due to a combination of genetic and environmental factors. Several risk factors have been identified that can increase the likelihood of developing bladder cancer. These include:

Smoking
Smoking tobacco is the most significant risk factor for bladder cancer. Chemicals in tobacco smoke are absorbed into the bloodstream and excreted in the urine, directly exposing the bladder lining to carcinogens.
Certain occupations involving exposure to chemicals such as aromatic amines, benzidine, and certain dyes and industries such as rubber, paint, and metalworking have been linked to an increased risk of bladder cancer.
Bladder cancer occurs more frequently in older adults, with the risk increasing with age. Men are more likely to develop it compared to women.
Advanced bladder cancer may cause persistent pain in the lower back or pelvis, which may worsen over time.
Bladder cancer can lead to changes in urinary habits, such as increased frequency, urgency, or difficulty emptying the bladder completely.
In some cases, bladder cancer may cause fatigue and unexplained weight loss, symptoms more commonly associated with advanced stages of the disease.
A diet low in fruits and vegetables and high in processed meats, as well as obesity, have been suggested as potential risk factors for bladder cancer.As with any surgical procedure, there is a risk of potential complications, such as bleeding, infection, blood clots, or damage to surrounding organs or structures.

It’s important to note that having one or more of these risk factors does not necessarily mean that an individual will develop bladder cancer. Conversely, some individuals with the disease may not have any known risk factors. Understanding the risk factors can help individuals make informed lifestyle choices and undergo appropriate screening or preventive measures when necessary.

What Are the Types of Bladder Cancer?

Bladder cancer can be classified into different types based on the specific cells that are affected. The main types include:

This is the most common, accounting for the majority of cases. It develops in the urothelial cells that line the inside of the bladder and can also occur in the lining of the ureters and urethra.

This type arises from squamous cells that form in response to chronic irritation or inflammation of the bladder, such as from long-term urinary tract infections or bladder stones. Squamous cell carcinoma is less common than transitional cell carcinoma and is often associated with advanced disease.

Adenocarcinoma of the bladder is a rare type of cancer that develops in the glandular cells of the bladder. It is more similar to cancers found in other organs like the colon or prostate than to typical bladder cells.

Less common types include small cell carcinoma, sarcoma, and lymphoma, and they account for a small percentage of bladder cancer cases.

The type of bladder cancer and its stage play a crucial role in determining the treatment approach and prognosis. A proper diagnosis is essential to guide appropriate treatment decisions, and healthcare professionals use various diagnostic tests, including biopsies and imaging, to determine the specific type and stage of bladder cancer in each case.

What Are the Stages of Bladder Cancer?

Bladder cancer staging refers to the process of determining the extent and spread of the cancer within the bladder and to nearby organs or lymph nodes. The stages are typically classified using the TNM system, which stands for Tumour, Nodes, and Metastasis. It ranges from non-invasive (limited to the inner lining of the bladder) to invasive (spreading into deeper layers of the bladder or beyond). Here is a general overview of the stages of bladder cancer:
Stage 0
The cancer is confined to the innermost layer of the bladder lining and has not invaded the bladder muscle or spread to nearby lymph nodes or distant sites.
The cancer has grown into the connective tissue layer beneath the bladder lining but has not reached the muscle layer or beyond. It has not spread to lymph nodes or distant sites.
The cancer has invaded the muscle layer of the bladder but has not spread beyond the bladder walls. It has not reached lymph nodes or distant sites.
The cancer has grown through the bladder muscle and may have spread to the surrounding fatty tissue. It may involve nearby organs or lymph nodes but has not spread to distant sites.
This is the most advanced stage and indicates that the cancer has spread beyond the bladder to nearby organs, lymph nodes, or distant sites, such as the bones, liver, or lungs.
Staging plays a crucial role in determining the appropriate treatment options and predicting the prognosis for bladder cancer patients. Various diagnostic tests, such as imaging, biopsies, and sometimes surgical exploration, are done to accurately determine the stage of bladder cancer in each individual case.

What are Bladder Cancer Treatments?

Bladder cancer is a type of cancer that starts in the cells of the bladder, the organ responsible for storing urine.

It can cause symptoms like blood in urine and frequent urination and requires various treatments depending on its stage and severity.

In Philippines, there are various treatment options available for bladder cancer. The specific treatment plan will depend on multiple factors, such as the cancer stage, the tumour grade, the patient’s overall health, and other individual factors.

Radiotherapy

Radiation therapy is a common treatment option for bladder cancer.

Immunotherapy

Immunotherapy is a type of cancer treatment that boosts the body’s immune system to recognise and attack cancer cells.

Targeted Therapy

Targeted therapy is an emerging treatment approach for bladder cancer aiming to target specific genetic mutations or pathways in cancer cells.

How common is bladder cancer in the Philippines?

Bladder cancer is less common in the Philippines compared with major cancers like breast, lung, and colorectal cancer, which account for a much larger share of total cancer cases nationwide.

Based on the IARC Global Cancer Observatory (GLOBOCAN 2022), the Philippines had an estimated 188,976 new cancer cases (all cancer types) in 2022. While bladder cancer represents a smaller portion of the overall cancer burden, it remains an important health concern, particularly because bladder cancer is generally more common in men.

Globally, bladder cancer is among the most commonly diagnosed cancers, with an estimated 614,298 new cases and 220,596 deaths in 2022.

Early evaluation and timely treatment are important, especially for symptoms such as blood in the urine, and patients are encouraged to consult a qualified doctor for proper assessment.

Meet Our Doctors

Our multidisciplinary team of oncologists in Philippines provide advanced care with a compassionate touch.

Dr. Angelo Miguel M. Realina
Palliative Care Specialist | Interventional Pain Management Specialist
Dr. Arthur Jason S. Go
Medical Oncologist
Dr. Beverly Ann P. Pineda
Medical Oncologist 
Dr. Carlo Ruperto P. Aguilar
Radiation Oncologist
Dr. Carlos Joseph T. Panaligan Jr.
Consultant Anesthesiologist
Dr. Claudine Yvette S. Gulapa
Anesthesiologist
Dr. Gonzalo C. Banuelos, Jr.
Radiation Oncologist
Dr. Jason King D. Talao
Medical Oncologist 
Dr. Jerickson Abbie S. Flores
Radiation Oncologist
Dr. Joel R. Tayo
Medical Oncologist
Dr. Jose Enrique Y. Montoya
Medical Oncologist
Dr. Karl Jeremy B. Lo
Radiation Oncologist
Dra. Kristine Anne B. Monte
Internal Medicine Specialist
Dr. Marwin M. Manalo
Medical Oncologist
Dr. Misael C. Cruz
Radiation Oncologist
Dr. Noel S. Chua
Medical Oncologist
Dr. Paulo S. Tioleco
Medical Oncologist
Dra. Rosalina P. Tongol
Internal Medicine

Breast Cancer

Personalised treatments designed to fight cancer while minimising side effects.

What is Breast Cancer?

Breast cancer is one of the most common cancers affecting women in Philippines and worldwide. It begins when abnormal cells in the breast grow uncontrollably and form a lump or tumour. Although breast cancer mainly affects women, men can also develop the disease. The three main subtypes are hormone receptor positive (ER/PR-positive), HER2-positive, and triple negative breast cancers. Each type behaves differently and requires specific treatment approaches.

How common is breast cancer in the Philippines?

Breast cancer is the most common cancer among women in the Philippines, accounting for about 1 in 3 new cancer cases in women.  

According to the IARC Global Cancer Observatory (GLOBOCAN 2022): 

  • Breast cancer made up 31.2% of all new cancer cases among women in the Philippines in 2022 (33,079 cases). 
  • The age-standardized incidence rate (ASR) for breast cancer among women was 60.3 per 100,000. 
  • Breast cancer was also a leading cause of cancer deaths nationwide, with an estimated 11,857 deaths in 2022.  

For comparison, cervical cancer was the third most common cancer among women in the Philippines in 2022, with 8,549 new cases and 4,380 deaths.  

These figures highlight why early detection and timely treatment of breast cancer remain crucial to improving outcomes and quality of life for Filipino patients and families. 

What Are the Signs and Symptoms of Breast Cancer?

Some common signs to look out for include:

Early breast cancer may not show symptoms, which is why regular screening, such as mammograms, is important for early detection.

Screening for Breast Cancer

Regular screening is the most effective way to detect breast cancer early, when treatment works best. In Philippines, breast cancer is often diagnosed at a later stage, making awareness and timely screening especially important.

Screening Options
  • Mammogram: The gold standard for breast cancer screening, recommended for women aged 40 and above, or earlier if there is a family history.
  • Ultrasound: Often used together with mammograms, especially for younger women or those with dense breast tissue.
  • Clinical breast examination: Performed by a doctor to check for lumps or changes in the breast.
  • Breast self-examination: Helps women become familiar with their own breast tissue and notice unusual changes, though it does not replace medical screening.
  • Women aged 40 years and above.
  • Women with a family history of breast or ovarian cancer.
  • Those with genetic risk factors, such as BRCA mutations.
  • Women with prior breast conditions or higher lifetime risk.
  • Detects cancer before symptoms develop.
  • Enables treatment at earlier, more curable stages.
  • Reduces the risk of advanced disease and improves survival outcomes.

How Breast Cancer is Diagnosed?

Diagnosis involves several steps:

What Are the Causes and Risk Factors of Breast Cancer?

What Are the Types of Breast Cancer?

  • Hormone receptor positive (ER/PR-positive): Cancers that grow in response to hormones
  • HER2-positive: Cancers driven by high levels of the HER2 protein, often more aggressive
  • Triple negative breast cancer: Lacks ER, PR, and HER2; tends to behave more aggressively
  • Less common types: Inflammatory breast cancer, Paget’s disease of the nipple, and male breast cancer

What Are The Stages of Breast Cancer?

Breast cancer stages range from early to advanced:
Stage 0

Ductal carcinoma in situ (DCIS), cancer confined to the ducts

Small invasive tumour with little or no lymph node involvement

Larger tumour or spread to nearby lymph nodes

Locally advanced, with more extensive lymph node spread or involvement of chest wall/skin

Cancer has spread (metastasised) to other organs, such as bone, liver, lung, or brain

What are Breast Cancer Treatments?

Treatment depends on cancer stage, subtype, and patient profile. In Philippines, there are various treatment options available for breast cancer. The specific treatment plan will depend on multiple factors, such as the cancer stage, the tumour grade, the patient’s overall health, and other individual factors.

Surgery

Lumpectomy (breast-conserving) or mastectomy, often with lymph node surgery.

Radiotherapy

To destroy residual cancer cells and reduce recurrence risk.

Hormonal Therapy

Tamoxifen, aromatase inhibitors, fulvestrant; sometimes combined with CDK4/6 inhibitors (Ibrance, Kisqali, Verzenio) for advanced cancer.

Targeted Therapy

HER2-directed treatments such as trastuzumab (Herceptin).

Immunotherapy

Used in certain triple negative breast cancers.

How common is breast cancer in the Philippines?

Breast cancer is the most common cancer among women in the Philippines, accounting for about 1 in 3 new cancer cases in women.  

According to the IARC Global Cancer Observatory (GLOBOCAN 2022): 

  • Breast cancer made up 31.2% of all new cancer cases among women in the Philippines in 2022 (33,079 cases). 
  • The age-standardized incidence rate (ASR) for breast cancer among women was 60.3 per 100,000. 
  • Breast cancer was also a leading cause of cancer deaths nationwide, with an estimated 11,857 deaths in 2022.  

For comparison, cervical cancer was the third most common cancer among women in the Philippines in 2022, with 8,549 new cases and 4,380 deaths.  

These figures highlight why early detection and timely treatment of breast cancer remain crucial to improving outcomes and quality of life for Filipino patients and families. 

Meet Our Doctors

Our multidisciplinary team of oncologists in Philippines provide advanced care with a compassionate touch.

Dr. Angelo Miguel M. Realina
Palliative Care Specialist | Interventional Pain Management Specialist
Dr. Arthur Jason S. Go
Medical Oncologist
Dr. Beverly Ann P. Pineda
Medical Oncologist 
Dr. Carlo Ruperto P. Aguilar
Radiation Oncologist
Dr. Carlos Joseph T. Panaligan Jr.
Consultant Anesthesiologist
Dr. Claudine Yvette S. Gulapa
Anesthesiologist
Dr. Gonzalo C. Banuelos, Jr.
Radiation Oncologist
Dr. Jason King D. Talao
Medical Oncologist 
Dr. Jerickson Abbie S. Flores
Radiation Oncologist
Dr. Joel R. Tayo
Medical Oncologist
Dr. Jose Enrique Y. Montoya
Medical Oncologist
Dr. Karl Jeremy B. Lo
Radiation Oncologist
Dra. Kristine Anne B. Monte
Internal Medicine Specialist
Dr. Marwin M. Manalo
Medical Oncologist
Dr. Misael C. Cruz
Radiation Oncologist
Dr. Noel S. Chua
Medical Oncologist
Dr. Paulo S. Tioleco
Medical Oncologist
Dra. Rosalina P. Tongol
Internal Medicine